BGEN 3020 Lecture Notes - Renal Vein, Lumpectomy, Medulloblastoma

• School: University of Manitoba
• Department: Biochem. and Medical Genetics
• Course: BGEN 3020
• Professor: Jason Leboe- Mcgowan

Document Summary

Derived from stem cells in the marrow and metastasize: malignant lymphoma: arise from lymph nodes, and can metastasize anywhere, include bm. The mc site in body for lymphoma not developing in lymph node: stomach. Most extranodal (outside lymph node) primary lymphomas occur in the stomach: pylori can produce these. 2nd mcc location (lymphoid organ in the gi tract) = payer"s patches (located in the terminal ileum). This is an example of knocking off apoptosis gene - 14:18 translocation of a heavy chain; when you get the translocation, b cells will make bcl-2, which inactivates apoptotic gene in the b cell, therefore, the apoptotic gene is immortal, leads to cancer. Nomenclature of trophoblastic tumors: hydatidiform mole, presents with cluster of grapes. It manifests in the first trimester with signs of preeclampsia (hp, proteinuria, edema in the first trimester). So, hydatidiform mole is a b9 tumor of the whole chorionic villus, and it looks like grapes b/c it"s dilated up.