BIOL 2500 Lecture Notes - Lecture 12: Dominance (Genetics), Allele Frequency, Genetic Drift

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Genetic drift can raise or lower the frequency of an allele in a small population every generation. Once allele frequencies are changed, the next generation begins with the new frequencies. Over multiple generations, the frequency of an allele will uctuate. In the absence of other evolutionary in uences, one allele will ultimately reach xation. Small population size provides the conditions under which sampling errors can produce signi cant genetic drift of allele frequency. Establishment of a new population by a small number of founding organisms can produce a difference in allele frequencies, and is called the founder effect. The allele frequencies of the new population may differ from the original population as a result of sampling error. The founder effect and genetic drift can result in high frequencies of autosomal recessive disorders that are rare outside the affected area. For example, the old order amish in pennsylvania were established by a founding population of about 200, between 1720 and 1770.

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