BIOL 2500 Lecture Notes - Lecture 18: High Fidelity, Nonsense Mutation, Transversion
28 May 2016
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Document Summary
Ever organism carries mutant alleles, whether they manifest in distinct phenotypes or not. Humans acquire one to four new mutations each generation. Mutations frequency is measure as the number of times mutation alters a particular gene. Number of mutational events in a give gene over a de ned period of time (most often per. Dominant mutations are easier to detect than recessive mutations and so are easier to study. Mutation frequencies are low in all genomes. Mutation frequencies vary among genes of a single species. Each species has an average mutation frequency; Localized mutations, or point mutations, occur at a speci c, identi able position in a gene. Such mutations have varies consequences depending on the type of sequence change and the location of the affected part of the gene. Base-pair substitution mutation: the replacement of one nucleotide base pair by another. Transition mutations; one during replaces another, or one pyrimidine replace another.
