MBIO 1010 Lecture Notes - Lecture 28: Corynebacterium Diphtheriae, Diphtheria Toxin, Septic Shock

• School: University of Manitoba
• Department: Microbiology
• Course: MBIO 1010
• Professor: Christopher Rathgeber

Document Summary

Lyse many cells (not just red blood cells) Produces streptolysin attacks sterols in the cell membrane. Attacks the cholesterol we have embedded in our membranes (= sterols: leukocidins destroy white blood cells, ex. Toxin subunits insert into the membrane and oligomerize to form a heptamer. Cell contents leak out and the cell dies: aureus"s alphato(cid:454)in appears to target leuko(cid:272)(cid:455)tes spe(cid:272)ifi(cid:272)all(cid:455) (cid:271)(cid:455) intera(cid:272)ting with complement receptors (spaan et al. , 2013). Heptamer = 7 different pieces and the insert together (multi - sub unit) and the poor allows extracellular to leak to the inside and outside. Diphtheria toxin (corynebacterium diphtheriae) : subunit b specifically binds to a protein on animal cells. Subunit a then moves across the membrane. Gene for diphtheria toxin is not encoded on the chromosome, but instead on a virus . Activate t cells to elicit an extreme immune response . Super antigens = hyper stimulate the immune system.