MBIO 2020 Lecture Notes - Lecture 1: Synaptonemal Complex, Sister Chromatids, Nuclear Membrane

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25 Nov 2017
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In sexual reproduction, gametes (reproductive cells) are produced; these unite during fertilization. Multicellular eukaryotes reproduce mainly sexually: males and females carry distinct reproductive tissues and structures, mating requires the production of haploid gametes form both male and female, the union of haploid gametes produces diploid progeny. Meiosis i: three hallmark events occur in meiosis i, 1. Segregation (separation) of homologous chromosomes, which reduces chromosomes to the haploid number. Leptotene and zygotene: chromosome condensation begins in leptotene stage, the meiotic spindle forms as microtubules extend out from centrosomes, the nuclear envelope disintegrates during zygotene, homologous chromosomes undergo synapsis. Synaptonemal complex: homologous chromosomes align and the synaptonemal complex (protein bridge) is formed between them, this tri-layer protein structure tightly binds nonsister chromatids of homologous chromosomes, nonsister chromatids belong to different members of a homologous pair. Diakinesis: kinetochore microtubules move synapsed chromosome pairs toward the metaphase plate. 2: here homologs align side by side.

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