MBIO 3010 Lecture Notes - Lecture 10: Mycobacterium Tuberculosis, Opsonin, Antigen
17 Nov 2016
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Organism releases toxins, phagocyte is killed by toxins. Organism (staphylococcus) produces protein which prevents interaction between opsonizing antibody and phagocyte, so preventing phagocytosis. Organism escapes from phagolusosome into the cytoplasm and replicates within the phagocyte. Organism resists killing by producing antioxidants ex. catalase in staph, or by scavenging free radicals. Produces toxin that inhibits ciliary action, and is able to attach to surface not that cilia are immobile. Makes the body more prone to secondary infection. Outer suface (ex. capsule) prevents either c activation of access to xed c3b. Bacterial membrane is resistant to mac complex formation. Decoy proteins divert c components away from bacterial surface. Higher af nity to iron than transferrin - pathogen steals the iron. Host cells respond to dsdna/rna from infecting microbes by producing inf. Some viruses are poor inducers of inf (ex. hepatitis b) or produce molecules that block action of inf in cells (hiv)
