HSC 350 Lecture Notes - Lecture 11: Pars Compacta, Medium Spiny Neuron, Substantia Nigra
Document Summary
These nuclei are important in the control of movement ; the selection and initiation of willed movements. Supervisory control" by regulating the activity of upper motor neurons. They respond in anticipation of and during movments. Selective lesion in the basal ganglia are the cause of parkinson"s & huntington"s diseases. The corpus striatum is input of the basal ganglia (consist of caudate, putamen) Medium spiny neurons integrates corpus striatum inputs from cortical, thalamic and brainstem structures. Orginated from (1) frontal cortex (2) parietal cortex (3) temporal cortex (4) substantia nigra par compacta (found the midbrain) into the (a) putamen & (b) caudate. The substantia nigra par compacta terminate in both the putamen and caudate. Corticostriatal pathway: caudate: having multimodal association cortices, motor areas in the frontal lobe that control eye movements. The putamen neurons discharge in anticipation of limb & trunk movement.
