MCIM 309 Lecture Notes - Lecture 5: Monoclonal Antibody, Immunogenicity, Passive Immunity
28 Jan 2017
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Injection of purified antibody: antibody containing serum or immune cells, maternal antibodies, prevent disease after exposure. Improve symptoms: protect immunodeficent, block action of bacterial toxin/venoms, monoclonal antibodies, t-cells, all use human except tetanus, botulism and diptheria use equine. Immune response after challenged with immunogen: vaccination. Large amount of antigen to produce antibody response. Killed, subunit, peptide, toxoid or vlp (resembles virus by no dna) Generate antibody (th2) rather than cell mediated. Administered with adjuvant that boosts their immunogenicity. T cell antigens may also be included. Inactivated influenza vaccines consist of mixture of the hemagglutinin and neuraminidase: live. Prepared microbes limited in ability to cause disease. Live vs attenuated: natural/injection injection, low dose high dose, single dose multiple doses, no adjuvant needs adjuvant, long term immunity short term. Igg and iga igm and igg: good cell mediated poor cell mediated, lability yes more stable, mild symptoms occasional sore arm.
