MCIM 309 Lecture Notes - Lecture 10: Arthropathy, Immunoglobulin M, Antibody

• School: U of S
• Department: Microbiology and Immunology
• Course: MCIM 309
• Professor: Dr.Muhammad Suleman

Document Summary

B19- only human parvo: called fifth disease in children, acute polyarthritis in adults. Bocavirus: acute respiratory disease, may be severe in young children. Structure: small, non enveloped, single stranded linear dna, plus or minus strands are packaged into separate virons, naked icosahedral, needs growing cells or helper virus for replication, ends of genome have hairpin loops. Replication: same as normal virus, mrna leaves nucleus renters with more structural/non structural proteins. Infects mitotically active erythroid precursor cells: large viremia, crosses placenta, causes biphasic disease. Circulating immune complexes do not fix complement. Leads to life threatening aplastic crisis: normal host. Most common in winter and spring: no modes of control. Syndromes: mild flu like, arthropathy (sore joints, fetal loss, slapped cheek appearance. After this isolating virus becomes very tough: non-infectious phase. Seronegative mother increases risk for fetal death. Seropostitive have no adverse effects on fetus: bocavirus. More severe on children under 2 yrs.