NUTR 120 Lecture Notes - Lecture 8: Malondialdehyde, Fish Oil, Dietary Fiber
Document Summary
Oxidation, free radicals and antioxidants: oxidation: leo = loss of electrons equals oxidation. Resulting compound is more reactive: oxidation and fats: Double bonds are more susceptible to oxidation. Polyun fatty acid free radical comes in and takes electron radical becomes stable and. Ldl oxidized oxldl (taken by macrophage) creates a foam cell. In lipoproteins: prevent this by antioxidants, connection to cancer, stages of cancer: Stage 1: initiation (any kind of dna damage) 99. 999999% of the time, the cell will die or repair itself; however, sometimes mutation will occur (called promotion: free radicals, uv lights, viruses. Step 3: progression (cells lose remaining control, and the rate of growth is exponential: grow so quickly that they start to accumulate other errors as well, metastatic tumor (metastasize to spread) Radicals can damage: dna (initiation, pufa oxidized pufa (minus electron) breakdown malondialdehyde (promotion, protein cataracts (due to free radical mediated oxidation of the protein in the lens of your eye)
