TOX 300 Lecture Notes - Lecture 7: Xenobiotic, Toxicokinetics, Dieldrin
Document Summary
*summary of adme linking it to toxic effects. Damage to the dna can be repaired. If it does(cid:374)(cid:859)t get repaired and is allowed to replicated it will create altered dna that can lead to cancer. The co-administration of two or more xenobiotics is often associated w/ altered clearance of one (or more) of the xenobiotics. We are always exposed to multiple xenobiotics from our environment. If another xenobiotic is present, it will not bind to albumin and is able to diffuse out into the tissues (cid:894)al(cid:271)u(cid:373)i(cid:374) has (cid:374)o (cid:858)seats(cid:859) left(cid:895: interactions during biotransformation. Induction and inhibition: phase 1 and phase 2 enzymes will either be induced or inhibited when exposed to a xenobiotic. If another substance has a higher affinity for the pump, it can outcompete other substances: a change in ph is a compartment of the body will affect the transport of the xenobiotic around the body.
