BIOL130 Lecture Notes - Lecture 7: Protein Kinase C, Protein Kinase, Lipid Bilayer

• School: University of Waterloo
• Department: Biology
• Course: BIOL130
• Professor: Heidi Engelhardt

Document Summary

Any cell in the body tht has a receptor for that signal has access to the molecule: very effective long range communication, neuronal. Ion channel: acetylcholine is a great example of a ligand that binds to the outside (extracellular part of an ion channel) causes shape change and ions rush in and muscle contracts. A (cid:272)ell"s (cid:396)esponse (cid:272)an (cid:271)e fast o(cid:396) slow: fast effects can be milliseconds, enzymes already present crank up activity easy, slow, activate transcription factor, goes to nucleus and signals transcription very slow, slow but powerful. The location of the receptor can usually be predicted by the chemistry of the signal molecule: depends on the chemistry of the signal/ ligand, b) have small molecule that likes lipid (hydrophobic) Do not cross bilayer but can act as signals by binding to the extracellular side of a membrane receptor protein: results in transduction across the bilayer.