BIOL308 Lecture Notes - Lecture 17: Euchromatin, Irf1, Ataxia
4 Feb 2015
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Helix in zn finger c6: leucine zipper part in bzip, second helix in bhlh. C6: one helix in homeodomain, basic helix part in bzip, basic helix in bhlh. Ligand binding domain: in zn finger c4 factors (steroid hormone is ligand) H3", h4 helices): when dexamethasone (ligand, works as glucocorticoid hormone) is bound coactivator src1 binds . Dimerization domain: one of the zn fingers, helix in zn finger c6, leucine zipper part in bzip, second helix in bhlh. Functional domains overlap: one helix in homeodomain, basic helix part in bzip, basic helix in bhlh. Ligand binding domain: in zn finger c4 factors (different ligands) Note: action at (up to 50 kb) distance: promoter and enhancers do not even have to be on the same chromosome. Stavros lomvardas,1 gilad barnea,1 david j. pisapia,1 monica mendelsohn,1 jennifer kirkland,1 and richard axel1, cell 126, 403 413, july 28,
