BIOL308 Lecture 4: Lecture 4

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Explain the chemical forces determining dna structure. Describe how base pairs can be identified in the major groove based on h-bond donors and acceptors. Describe the conformational features of a, b, and z dna structures and when each structure occurs in vivo. Within individual molecule and between oppositely charged ions (huge difference in electro-negativity) Polarity: h atom covalently attached to a very electronegative atom (n, o or p; donors, d) has partial positive charge. Partially positive h could be attracted by another electronegative atom (acceptor, a) and it can form a weak hydrogen bond with it. Between all types of molecules (nonpolar and polar) Cause is transient, unequal movement and distribution of electrons formation of temporary dipoles; Dipole of one molecule helps electrons of the second molecule to arrange into dipole (+ve attracts ve) . Those interactions decrease with distance, but if too close - repulsion.

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