BIOL444 Lecture Notes - Natural Killer Cell, C5-Convertase, Innate Immune System
25 Dec 2012
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Document Summary
Set 02 overview of the immune system. Innate vs. adaptive immune responses (adaptive is unique to jawed vertebrates) Wbc (leukocytes, e. g. neutrophils or macrophages) patrols for foreign substances @ all time. Inflammation initiates innate immune response to limit damage. Mast cells that circulates in the blood releases vasodilator molecules (e. g. prostaglanding, Vasodilation of blood vessels ( diameter) blood flow to damaged site: redness & in local temperature (37 c) Capillary permeability movement of immune cells, antibodies, clotting factors, complement factors & fluids to damaged tissue (passive extravasation: local swelling, painful edema (bradykinin produced & binds pain receptors) Antibody & complement factors binds bacteria phagocytes engulfs bacteria. Cell signalling, inflammatory molecule, cytokines in *], creates a chemical gradient . Actively recruits leukocytes phagocytes from the circulatory system. Epithelial cells of blood vessel (endothelium) expresses adherence receptors (icams) that specifically grabs passing immune cells out of the vessel into the tissue facilitate extravasation & clotting.
