T cell maturation
1. Originate in red bone marrow of bones – migrate to thymus. Thymus is specialized organ where
thymocytes mature. Divided into: subcapsular region, cortex, corticomedullary junction and
medulla. (As maturation goes on, the thymocytes travel through all these regions.)
2. T cell progenctors/parent enter in high endothelial venule and migrate to subcapsular region
where these theymocytes start maturation by rearrangement of T cell receptor gene.
3. As maturation goes on, cells express specific receptor, migrate to cortex.
4. MHC peptide complex and T cells receptor displayed by thymic epithial cells, thymocytes
displayed both CD4 and CD8 and a/B T cell receptors
5. Cell receptor able to recognize an MHC Class 1 mol