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BIOL 153 (51)
Lecture

T cell maturation.docx

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Department
Biology
Course
BIOL 153
Professor
Robert Harris
Semester
Summer

Description
T cell maturation 1. Originate in red bone marrow of bones – migrate to thymus. Thymus is specialized organ where thymocytes mature. Divided into: subcapsular region, cortex, corticomedullary junction and medulla. (As maturation goes on, the thymocytes travel through all these regions.) 2. T cell progenctors/parent enter in high endothelial venule and migrate to subcapsular region where these theymocytes start maturation by rearrangement of T cell receptor gene. 3. As maturation goes on, cells express specific receptor, migrate to cortex. 4. MHC peptide complex and T cells receptor displayed by thymic epithial cells, thymocytes displayed both CD4 and CD8 and a/B T cell receptors 5. Cell receptor able to recognize an MHC Class 1 mol
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