IMM340H1 Lecture 7: Lecture 7.2
Document Summary
The role of the thymus in t cell development. Hematopoietic stem cells give rise to t cells: hematopoietic stem cell in the bone marrow can give rise to the common lymphoid or the common myeloid progenitor, myeloid lineage. The thymus: small organ above the heart, after puberty the thymus shrinks steadily over time. Cellular environment within the thymic lobule: single lobule. Thymic stromal cells support thymocyte development: scanning electron micrograph of the thymic cortex, smooth round balls are the developing thymocytes, when early thymic precursors first arrive in the thymus, they have. Signaling through notch-1 induces commitment to t lineage vs b lineage: well known stroma cell ligand binds to a protein on the precursor cells called. In the case of lymphoid precursor cells that enter the thymus the fate of the decision is whether the developing lymphocytes will develop into b cells or t cells.
