MICB 202 Lecture Notes - Lecture 3: Mhc Class Ii, Memory T Cell, Hematopoietic Stem Cell Transplantation
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Inflammatory response: damaged mast cells and epithelial cells release chemicals for pain, mast cells release histamine to dilate bv (pain, swelling, redness, warmth, resident macrophage release. Is a cytokine: sticky + leaky recruit plasma which has complements, neutrophils, monocytes, and dendritic cells. *c3b is an opsonin, it also forms part of c3 convertase. Mac: other functions of complements, c3a: inflammation. Increase permeability by stimulating macrophage to produce more tnf: c3b: opsonin. Phagocytic cells have receptors for opsonins, therefore increase contact points. And are codominantly expressed so you have 6: since they are proteins, has high level of turn over, mhc 1 vs mhc ii. Alpha chain, b chain not covalently bonded to it. Peptide binding groove in alpha . present to. Present to th a. a. 13 , drapes over groove. Only in apcs: macrophage, dendritic, b cell, thyroid epithelial cells. Migrate to thymus: begin to express tcr that"s generated randomly thru splicing of gene segments (each cell has 30,000identical copies)
