PCTH 201 Lecture Notes - Lecture 1: Histamine Receptor, Paracetamol, Salbutamol

• School: UBC
• Department: Pharmacology and Therapeutics
• Course: PCTH 201
• Professor: Andrew Horne

Document Summary

Their: sources/origins, appearance/nature, chemistry/composition, actions/effects, uses particular those that make a drug medically effective. Note: pharmacology requires the integration of all other scientific disciplines. Multi-faceted: general principles of drug action (pharmacodynamics/pharmacokinetics, systems/organ pharmacology. Cardiovascular pharmacology: toxicology, clinical pharmacology, pharmacoepidemiology, pharmacogenomics. What is a drug: (cid:862)a (cid:374)o(cid:374)-food substance used in the prevention, diagnosis, alleviation, treatment or (cid:272)ure of disease(cid:863) (adaptatio(cid:374) fro(cid:373) ted(cid:373)a(cid:374)"s medi(cid:272)al dictionary, most broad definition: Receptors: act as binding partners for a drug inside the body. Receptors may be: a specialized structure (usually protein) designed to bind to a drug (specialized receptor) Transmembrane structure e. g. g protein coupled receptor. Intracellular complex e. g. transcription factors in dna replication: a (cid:373)ole(cid:272)ule sta(cid:374)dard to a (cid:272)ell"s fu(cid:374)(cid:272)tio(cid:374) or regulatio(cid:374), (cid:449)hose a(cid:272)ti(cid:448)it(cid:455) (cid:272)a(cid:374) (cid:271)e (cid:373)odified by drug interaction (generalized receptor) #1 receptor numbers & selectivity: many different receptor families throughout body, vary in structure. 2nd messenger cascade (what they do when activated)