PCTH 201 Lecture Notes - Lecture 5: Adenosine Receptor, Cyp1A2, Receptor Antagonist
26 Sep 2017
School
Department
Course
Professor
Document Summary
The drug: naturally occurring compound (over 60 known plants, most widely used psychoactive drug worldwide, member of the methylxanthine family. Sources: pills, chocolate, soda, energy drinks, coffee, etc. Natural sources: species of plants, weather, soil, darker roast. How much caffeine is in these sources? e. g. coffee: ~100mg/cup (250 ml) (primary) caffeine effect. Stimulant effect on central nervous system: decreased fatigue. Improved performance on motor and memory tasks (other) caffeine effects: constricts cerebral blood vessels. Headache relief: stimulates acid release from gastric mucosa. Tremors ( )at higher doses: mild diuretic effect. Not relevant when consumed as a beverage. Adenosine triphosphate (atp: e(cid:374)ergy (cid:862)(cid:272)urre(cid:374)(cid:272)y(cid:863) for all (cid:272)ells of the (cid:271)ody, cleavage of phosphate groups energy release. Note: as atp is depleted in response to cellular energy demands adenosine levels increase. Adenosine receptors: localized in neurons and cell membranes, stimulated by high concentrations of adenosine. From high levels of amp, from high levels of adp: with respect to cell activity, stimulation is inhibitory.
