PHAR 441 Lecture Notes - Lecture 2: Cyp3A4, Vaginal Bleeding, Coronary Artery Disease

• School: UBC
• Department: Pharmaceutical Sciences
• Course: PHAR 441
• Professor: Arun Verma

Document Summary

** see sex hormone notes for details about the menstrual cycle that we should know. Prevention of ovulation - mechanisms of combined estrogen-progestin. Negative feedback suppression of gonadotropin secretion synergistic effect of estrogen and progestin fsh production (<70% normal) mid- cycle fsh release is blocked minimal follicular development and no. Uncoordinated contractions of fallopian tube and uterus impair transport of sperm and ovum. Cervical mucous is thicker and more viscous impairs sperm penetration. Endometrium is atrophic (thin and poorly developed) impairs implantation. Estrogen component: ethinyl estradiol is the only estrogen in o. c. It is orally active, more potent, and has a longer duration than naturally occuring estrogens: the only variation is the dose. Progestin component: many different progestins used with varying degrees of progestin potency and other hormonal activity, the variation between preparations is based on type and dose of progestin.