PSYC 207 Lecture Notes - Lecture 25: Vasopressin, Depressant, Disinhibition
Document Summary
Gaba-a receptors are chloride channels, will hyperpolarize the cell. Chronic administration of alcohol: # of gaba-a receptors decrease. Increase function of gaba receptors = increases opioid neurotransmitter release into vta. By activate gaba receptors = you inhibit gaba neuron/inhibit the inhibition onto. Glutamate is primary excitatory system, if you inhibit it = depressant effects. When you stimulant nmdars you see short and long term changes in how the cell responds. Cell senses its a strong connection and strengths it even more, creating memories. Mg2+ blocks nmda receptors, meaning glutamate binding doesn"t affect it. If you depolarize the inside of the cell, it pushes the mg2+ out, now glutamate can bind and ions will flow through the receptor. Allows passage of calcium - used as a signalling molecule (add more receptors, changes in proteins/rna), makes the dendrite more sensitive. If you block nmdars = block the formation of memory = forgetfulness/blackouts when drinking a lot.
