PHAR 562 Lecture Notes - Lecture 3: Permeation, Pdz Domain, Ifenprodil
14 Oct 2017
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We will learn about 3 types of glutamate receptors: nmda, ampa, kainite. Nmdars: slow gating, coincidence detection: very important for development, detrimental to life if removed from the organism. Kars: regulators of neuronal circuits: not essential for life like nmdars, are more like accessory receptors that help in neuromodulation. Ampa and nmdars form the hardwiring of the glutamate receptor synapses so they are required for life: they work together iglur subtypes offer the brain signaling diversity. Important in development therefore not having them = detrimental to life (organism will not be born) Form the hardwiring of glutamate receptor synapses. Have fast activity (within 1ms) and very quickly bind with glutamate to respond within hundreds of ms. Extremely fast gating and almost map the timing of glutamate in the synaptic cleft. Important bc these receptors depolarise neurons to between -40 and -50mv allowing na channels to open and action potentials to occur. These receptors stay open for just a few ms.
