BCH 2333 Lecture Notes - Lecture 4: Histidine, Chief Operating Officer, Artillery Observer
26 Jan 2016
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Document Summary
Most amino acids are chiral all except glycine. Aliphatic nonpolar amino acids: gly, ala, met, val, pro, leu, ile. Except pro, gly, tyr,trp who can sometimes behave like: all amino acids with alkyl r-groups, generally hydrophobic polar amino acids, pka ammonium = 9. 2, pka alpha carboxylic acid = 2. 2, glycine simplest amino acid. Non stereogenic bc 2 substituents are the same (no side chain: methionine. S = not very en, non-polar side chain. All drawn in fischer rosenhof convention: all bonds are assumed to be going into/coming out of page as, valine ; aliphatic = greasy side chain around them; bigger learned. Similar to ch2 in size and polarity: proline. Side chain has 3 carbons that connects to the secondary amine amino acids; more side substituents. Isopropyl unit: leucine & isoleucine are regioisomers. Aromatic nonpolar amino acids: tyr, trp, and phe. Isoleucine has a second stereogenic center: tyrosine. Has a phenol group (weak acid pka = 10. 1)
