BIO 1140 Lecture Notes - Lecture 13: Bcl-2-Associated X Protein, Protein Isoform, Futile Cycle
8 Oct 2016
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Gf bind to receptor, dimerize, autophosphorylate and recruits adapter protein, recruit ras, increase affinity to gtp, activated causes secondary messenger mapk which leads to ap-1. Ip3 can also bind to channel and allow calcium to be released. Phospholipase c has sh2 domain so doesn"t need adapter, bind directly to receptor which activates enzyme, enzyme has a target pl called pip2, binds to it and releases. Ip3 and dag (both have ability to function as second messenger); ip3 binds to calcium channel on er (leads to apoptosis, activate protein kinases (protein kinase. C), help kreb"s cycle, muscle contraction, releasing cell vesicles; all pathways interrelated) Because it is a fatty acid anchored protein. 2012 chemistry nobel for their work on structure and function of gpcrs: brian kobilka crystallography structure, robert lefkowitz md-biochemist, signalisation adrenergic receptors, worked with adrenal gland. Receptor for ligand on extracellular side, change conformation for the 7 spans.
