BIO 1140 Lecture Notes - Lecture 12: Cell Adhesion, Nuclear Membrane, Lysosome
12 Mar 2018
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Document Summary
They target proteins in the nucleoporins, everything that is cytoskeletal, they can digest anything made of proteins in the cell. Apoptosis involves fragmentation of the dna, cell-signalling pathways, activation of cellular enzymes and digestion of cellular contents by scavenger cells. But not lysis of the cell, that is part of necrosis: apoptosis is trying to limit the damage to the damaged cell only, there are 2 pathways: intrinsic and extrinsic, but we will only focus on intrinsic one. Caspases are proteins that break up peptide bonds in cleave proteins. First things you can observe: cytoplasm reorganizes itself, cytoskeleton shrinks, cells detach, chromatin condenses. It is easier to breakdown and package, package the dna since it makes up most of the nucleus. It stops pro apoptotic proteins mitochondria and interacts with der) It activates more pro-apoptotic proteins: bad activates bax and bak. On the er, there are channels to release calcium, bcl2 makes it difficult for er to release calcium.
