BIO 3124 Lecture 3: M3.L3. November 1st Lecture
25 Jan 2018
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November 1st lecture (slide 423 slide 453) Three types: a, b and c, types a and b affect humans, type c does not. Tropism (what kind of cells it infects): epithelial cells of the respiratory passage (tract) It infects these epithelial respiratory cells by recognizing the sialic acid receptors. Segmented (-) rna, 8 segments: segmented, meaning that it has 8 different chromosomes. Given that the cell cannot provide the rdrp, it brings its own with it, therefore each chromosome has one molecule of an rdrp. M1 protein: scaffold protein capsid, used to make the capsid. Involved in release (of the virus inside the cell) Rna dependent rna polymerase: required for viral replication. Neuraminidase on the virus spike and hemagglutinin. Tropism: cells of the immune system, t, monocytes and macrophage (cellular) receptor: cd4. +rna genome, 2 copies (positive, has 1 chromosome) Influenza: 8 chromosomes with 1 copy of each (haploid: hiv: 1 chromosome, 2 copies of it (diploid)
