BIO 3147 Lecture Notes - Lecture 5: Methyl Group, Genomic Imprinting, Histone Deacetylase
Document Summary
Can be classified by amounts of cpg content. Rick cgp are usually dealing with genes for development and are usually always on or at least poised. The way these things are regulated is at the methylation of the histones, not the dna level. Bivalent chromatic modifications will cause the gene to be poised. This class of promoters is classified with fully matured cells. The low cpg tend to be expressed at the later stages. The default state for the low cpg genes is the inactive state. In one model they are arguing that the methylated dna recruits a factor which recruits a deacetylases. In the other model, they recruit those methyltransferases which recruit methyls which will methylate the histone. Ways to inhibit transcription using a methyl group on dna to influence histone control. Two dna methyltransferases are critically important in modifying dna. Effects in the dna can be transmitted down the road to the histones.
