BIO 3153 Lecture Notes - Lecture 10: Spindle Apparatus, Anaphase-Promoting Complex, Sister Chromatids
Document Summary
Prophase is when the mitotic spindle begins to form. Chromosome condensation is very important, because they must get organized in order to set themselves up for division. Sister chromatids go to opposite ends of the cell. At prometaphase we have the breakdown of the nuclear envelope, releasing all the genetic material. Prophase we have the mitotic spindle cattling" the chromosomes to each cell. Metaphase is when the sister chromatids move to different spindle poles. There"s an important upregulation in dynamic change in the mitotic spindle. M-cdk activation leads to a decrease in map activity and an increase in. This causes an increased dynamic change in mts. So, as we"re approaching mitosis, there"s an increase in mt catastrophes. This is to facilitate formation of the mitotic spindle. Divide into astral, kinetochore and overlap mts. Kinetochore microtubules are those which are associated with the kinetochore of the chromosome pair.
