BPS 2110 Lecture Notes - Lecture 16: H2 Antagonist, Viscosity, Diffusion Layer
19 Nov 2016
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General principle of cancer treatment- the drug has to enter the cell in order to kill it. Table 4: drugs pumped out of the cell by p-gp include: Inhibiting efflux transporters expression (cid:1720) p-gp can be inhibited by the following drugs: Somebody can be suffering from an illness a but if p-gp is a problem, the person can be given a drug to inhibit the function of p-gp. When they take this drug before the other drug, the treatment drug will remain in the cell and have a therapeutic effect. Prodrug formulation: prodrugs the chemical modification of a drug aimed at the enhancement of solubility and permeability, prodrug strategy can be applied to: (cid:1720) water-insoluble hydrophobic drugs (cid:1720) hydrophilic drugs. Generally if you want to increase solubility, change the drug into its salt form-especially important for hydrophobic drugs. Another approach, link the drug to a substrate. Once inside a catalytic cleavage will free the drug.
