Pharmacology 2060A/B Lecture Notes - Lecture 3: Fluid Compartments, Malnutrition, Adipose Tissue
16 Jan 2017
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3. 1 body compartments (cid:137) drugs distribute into compartments in the body where they may be stored, metabolized, excreted or exert their pharmacological effect. (cid:137) the body"s compartments include: Interstitial space the extracellular fluid that surrounds cells. Low molecular weight, water soluble drugs distribute in the interstitial space. Total body water includes the fluid in the interstitial space, intracellular fluid and the plasma. Plasma the non-cell containing component of blood. Drugs strongly bound to plasma protein and high molecular weight drugs typically distribute in plasma. Lipid soluble (lipophilic) drugs distribute into adipose tissue. Muscle some drugs bind tightly to muscle tissue. Bone some drugs adsorb onto the crystal surface of bone with eventual incorporation into the crystal lattice. Bone can be a reservoir for the slow release of some drugs. In well perfused tissues such as the liver, kidney and brain, drug distribution is rapid.
