BPS 2110 Lecture 5: 2 - Biological Targets
25 Jan 2018
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Chain is modified so the assembly units are hidden Only need 1 enzyme system for each biomolecule type. Easily dis-assemble complex structures and regenerate parts for re-use. Have well defined three dimensional shapes -- always chiral. Drugs produce effects by binding to biological molecules. All drugs have to make physical contact in order to create a biological response. Differ from each other by their side chains. Non-polar side chains: alanine, valine, leucine, isoleucine, methionine, phenylalanine, tyrosine, Acidic side chains: aspartic acid, glutamic acid - act as bases at ph 7. 4. Basic side chains: lysine, arginine, histidine -- protonated and act like weak acids at ph 7. 4. Polar side chains: aspagine, glutamine, serine, cysteine, threonine. Sequence of aa in a protein (only info specified by a gene) Amino acids are joined by peptide bonds (amide bonds) (amino acid of one attaching to the carboxylic acid of the next)
