BPS 2110 Lecture Notes - Lecture 3: Lead Compound, Bioassay, New Drug Application

• School: University of Ottawa
• Department: Biopharmaceutical sciences
• Course: BPS 2110
• Professor: Robert Ben

Document Summary

Clinical trials: understand the nature of the disease or condition that you are going to treat or cure, understand where will you intervene in the disease pathology, consider hiv, there are a number of places in the viral life cycle for intervention. Identify a lead compound : how do you find something like this, rational design, accidental discovery, nature (takes a lot of time to screen for potential drugs, developmental of a bio assay, the bio assay has to be highly efficient; high throughput screen, 5% of compounds will succeed, chemical synthesis, replicating and optimizing b) a lead compound. Improve efficacy and efficiency along with solubility of lead compounds: testing toxicity and activity in appropriate models. a) Toxicity test not often done in humans: often done in vitro and in vivo, maximum doses given to test toxicity, keeps drugs safe, extremely expensive, phase i.