CHM 4123 Lecture Notes - Lecture 8: Active Ingredient, Stereoselectivity, Atom Economy

• School: University of Ottawa
• Department: Chemistry
• Course: CHM 4123
• Professor: Michael Organ

Document Summary

Lecture 8 active pharmaceutical ingredients and process chemistry. = a chemical or biochemical entity with a pharmaceutical product that exert the desired pharmacological effect in the body. Products can contain more than one api (combination products) Formulations can be either: tablet, capsule, pre-filled syringe. Discovery chemists = to produce a large number of compounds as quickly as possible. Process chemists = purity, formulation, intellectual property, reaction selectivity, material availability. Personnel; organic chemists, chemical engineers, analytical chemists, process safety specialists and occupational hygienists. Chemical synthesis most common method of synthesis obtained through chemical reactions. Batch/semi-batch synthesis(most common) fixed amounts are put into vessels to react and yield. Synthesis on solid supports used for peptides and easy purification. Continuous processing materials continuously being fed into and taking out of reaction. Biological synthesis fermentation of single celled microorganisms, recombi dna and monoconal antibody tech. Semi-synthetic apis- can be produced by a combination of methods, large scale fermentation and chemical synthesis.