HSS 3106 Lecture Notes - Lecture 19: Testicular Atrophy, Anabolic Steroid, Menorrhagia
6 Apr 2017
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Document Summary
Theca cells in the ovary respond to lh stimulations by secretion of testosterone, which is converted into estrogen by adjacent granulosa cells. Luteinizing hormone turns the follicle into the corpus luteum by triggering ovulation. Lh is required for continued development and function of corpus lutuea. In the testes, lh binds to receptors on leydig cells, stimulating synthesis and secretion of testosterone. Stimulates ovary to produce steroids (ovary will produce estradiol during follicular phase and progesterone during luteal phase) Stimulates sertoli cells to produce androgen-binding protein (abp), thereby stimulating spermatogenesis. Also stimulate sertoli cells to produce inhibin, which provides negative feedback to the anterior pituitary to decrease fsh secretion. If you take hormones, you turn off the production of natural testosterone and so testes shrink and they no longer produce enough testosterone. Structural: promote formation of female secondary sex characteristics, stimulate endometrial and uterine growth, maintenance of vessel and skin, reduce bone resorption, increase bone formation.
