HSS 2305 Lecture Notes - Lecture 13: Protein Kinase A, Inositol Trisphosphate, Adenylyl Cyclase

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 2305
• Professor: Keir J Menzies

Document Summary

Review adenyl cyclase: camp second messenger signalling pathway. G protein-coupled receptors: cgmp second messenger signalling (light triggered cell signalling) Mechanisms through which cell membrane phospholipids can become second messengers. G protein-coupled receptors: ip3 and dag second messenger signalling (dag: protein kinase c signalling, ip3: ca++ signalling) Role of pkc and ca++ signalling in human health and disease (cancer and fertilization) There are two major routes of message transmission: the binding of a ligand results in the generation of an intracellular second messenger via an effector enzyme. G protein-coupled receptors: effectors and 2nd messengers (camp: cyclic amp stimulates protein kinase a (pka, a fraction of pka is translocated to the nucleus through p-creb, creb is the camp response element-binding protein. Transcription factor that binds to cre response element (tgacgtca: increase transcription of camp sensitive genes (ie. gluconeogenesis) G protein-coupled receptors: effectors and 2nd messengers (cgmp: g(ta)"s associated effector is cgmp phosphodiesterase, which decreases its second messenger cgmp.