HSS 2305 Lecture Notes - Lecture 12: Glycogen Synthase, Phosphatidylinositol, Cytoskeleton
17 Nov 2016
School
Department
Course
Professor
Document Summary
The basic elements of cell signalling systems. A survey of extracellular messenger and their receptors (autocrine, paracrine, and endocrine signalling) Basic structure and function of g protein-coupled receptors. Mechanism of signal transduction in g protein-couple receptors. Difference between gs, gi, gq, and gt receptors. G protein couple receptors - camp second messenger signalling (epinephrine signalling and glucose regulation) Examples of human diseases that result from abnormalities in g protein-receptors/signalling. Cell signalling: overview: cells must respond adequately to external stimuli to survive via cell signalling. Cell has receptors on its surface that respond to the messenger. Cells induce or suppress themselves: send and respond to the same message. Messenger molecules travel short distances through extracellular space. Messenger molecules (hormones) reach their target cells through the bloodstream. Messenger travels far from the site of secretion to reach the target tissues/ organs/cells. Cell signalling: signal transduction: extracellular messages/signal molecules are ligands.
