HSS 2305 Lecture Notes - Lecture 12: Radio Television Of Kosovo, Colorectal Cancer, Adenylyl Cyclase

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 2305
• Professor: Kier J Menzie

Document Summary

Regulators of g-protein signaling(rgss): stops the response catalyst of gtp hydrolysis to gdp + pi. Phospholipids to second messengers: phosphate to pi by phospholipid kinase forms pip2, ligand binding to receptor + activation of g-protein- gdp ->gtp on gaq, gaq activates plcbeta, plcbeta cuts pip2 => ip3 & dag. Ip3 bind withca2+ channel for ca2+ regulation on ser /ca2+ release. Rtk: ligand binding rtk receptor dimerization + can have 1 or 2 ligand binds, rtk trans-autophosphorylation-phosphate added to tyrosine residue, brings relay proteins to the receptor for phosphorylation +activation of cellular response. Ligand binding rtk, active rtk-autophosphorylation plcy activation, pip2 dag,ip3. Active rtk phosphorylation irs docking protein, brings pi3k, pi3k phosphorylates lipids [pip2 pip3] Brings pdk1, pdk2 & akt, akt phosphorylated on thr 308 & ser 473 conformational change +activation. Insulin binding to rtk receptor -> dimerization added phosphate to tyr.