HSS 2305 Lecture Notes - Lecture 14: Cyclin D1, Mitogen, C-Jun N-Terminal Kinases
19 Nov 2016
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Document Summary
Rtk signal transduction (3 major signalling pathway) Overlap of mapk signalling across rtk and gpcr. Description of convergence, divergence, and cross-talk in cell signalling. Triggers activation or inhibition of adenylyl cyclase (effector) Increase/decrease in cytosolic camp which alters activation of. Decrease in cytosolic cgmp closes cation (na+) channels causing membrane hyper polarization. Therapeutic targeting of rtks in cancer: activation of certain growth factors receptors is implicated in tumour cell growth, tumour cells require blood supply to grow, can develop their own supply through angiogenesis. Tumour cells secrete angiogenic growth factors that stimulate endothelial cells lining nearby vessels. Some tumours also require activation of certain growth factor receptors (ie. epidermal. Gf receptor and rem) in order to grow and spread throughout the body: of the angiogenic factors produced by the tumour, vascular endothelial growth factor (veg-f) is the most important. Veg-f binds to speci c receptors located endothelial cells lining nearby blood vessels.
