HSS 2342 Lecture Notes - Lecture 9: Lipoprotein Lipase, Childhood Obesity, Adipose Tissue

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 2342
• Professor: Keir J Menzies

Document Summary

It is now estimated that 60% of canadian adults are overweight (bmi>25) or obese (bmi>30: childhood obesity is also on the rise, this cost to the health-care system is in the billions of dollars annually. Fat cell development: energy in > energy out, store in fat cells of adipose tissue, body fat reflected in the number and size of fat cells. Hormone-sensitive lipase: hsl: the key enzyme for fat mobilization from adipose tissues to the rest of the body, stimulated by, epinephrine, norepinephrine, glucagon, growth hormone etc. Let"s (cid:271)e (cid:272)lea(cid:396) a(cid:271)out lipases: lipoprotein lipase (lpl) is activated by insulin and it favors tg accumulation in adipose tissue whereas hormone-sensitive lipase (hsl) is activated by stress hormones (glucagon etc) and causes lipid mobilization from stores. One reason - the a(cid:272)ti(cid:448)it(cid:455) of this lpl i(cid:374)(cid:272)(cid:396)eases t(cid:396)ies to regain fat into cells this is just o(cid:374)e i(cid:374)di(cid:272)ato(cid:396) of a(cid:374) e(cid:454)isti(cid:374)g (cid:271)od(cid:455) (cid:862)set poi(cid:374)t(cid:863) fo(cid:396) weight: fat oxidation lower in obese individuals.