MUS 1301 Lecture Notes - Lecture 3: Generalized Anxiety Disorder, Deep Brain Stimulation, Venlafaxine
8 Feb 2017
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Palpitations, trembling, dyspnea, chest pain, nausea, feeling dizzy, paresthesia, derealisation, depersonalization, agoraphobia. Out of proportion fear of social situations. Rx: psychotherapy or drugs, ssri, benzos, beta blockers. Excessive anxiety, worry, restlessness, easily fatigued, difficulty concentrating, muscle tension, poor sleep. U_____ mechanism of action- doesn"t (cid:271)ind to gaba or benzodiazepine receptors. Compulsions: pt driven to perform act to ignore/supress obsession, ex. Repetitive behaviours: pt knows it is irrational. Rx: exposure therapy + ssris/ clomipramine, deep brain stimulation after 4 drugs fail, 12 months 40% symptom reduction. After a severe traumatic event: fear, helplessness, horror. Rx: therapy + drugs (ad, benzo, aed, antipsychotics, none show proven efficacy. Modafinil/armodafinil increase activity of cns neurons: enhance excitation/decrease inhibition. * antidepressants selectively elevate mood, so can stimulants (amphetamine, methylphenidate) Increase wakefulness/alertness, reduce fatigue, improve performance: confidence, euphoric, inc motor activity , suppress appetite, reduce pain perception, unique, non amphetamine stims, promote wakefulness in narcolepsy, adhd and fatigue associated with.
