PHS 1200 Lecture Notes - Lecture 1: Mitral Valve Prolapse, Mitral Valve Stenosis, Congenital Heart Defect

• School: University of Ottawa
• Department: Physiology
• Course: PHS 1200
• Professor: Frank Feiner

Document Summary

Incidence increased rapidly during 20th century, peaked late (cid:883)96(cid:882)"s. Then decreased because of improved treatment and prevention. Nonetheless, leading cause of death globally: 17. 5 millions people died in 2012. Coronary heart disease (coronary artery disease of artherosclerotic coronary vascular disease) Diseases of the layers of the heart: cardiac valve and other endocardial disease, diseases of the myocardium, diseases of the pericardium. Gives mode of intervention (diet, exercise, and drugs) Positive risk factors: increasing age, african american race, htn, diabetes, cigarette smoking, low. To calculate 10 year ascvd risk use: framingham risk prediction score. Probability due to abnormal lipid metabolism: lipids (cholesterol/triglycerides) move in blood within lipoprotein spheres, surface apoproteins direct binding to peripheral tissue, chd risk varies with type of lipoprotein. Low density and very-low density: lipoprotein ldl and vldl increase risk (transport cholesterol from liver peripheral tissues where it forms atheromatous plaques. High density lipoprotein: hdl decreases risk (transport cholesterol from peripheral tissues liver removing plaque)