PHS 4300 Lecture Notes - Lecture 2: Megakaryocyte, White Blood Cell, Hematocrit

• School: University of Ottawa
• Department: Physiology
• Course: PHS 4300
• Professor: Joanne Savory

Document Summary

Hematocrit: % of blood volume occupied by rbc. Most abundant (4. 2 6. 2 million cells/ul) Transport o2 to tissues & remove co2 from tissues. Act primarily in tissues but circulate in blood & lymphatic system. 5000 10,000 /ul of blood protect the body by phagocytosis of microorganisms form immune antibodies. Thrombocytes (platelets) circulating cytoplasmic fragment of megakaryocytes form blood clots and control bleeding release cytoplasmic granules involved in the hemostatic process. 150,000 400,000 platelets/ul one third of body"s platelets are in reserve (in the spleen) Cbc determines the number of rbc, wbc, and platelets per unit of blood. Wbc differential count is a measure of the relative %s of the individual wbc. Inspection of a blood smear will identify morphological abnormalities such as a change in size, shape or color of cells. Requirements: stem cells, erythropoietin, iron, folate, vitamin b12. Reduced number of rbc or low levels of hb resulting in decrease/impairment in 02 carrying capacity.