BIO200H5 Lecture Notes - Lecture 13: Osteoporosis, Transferase, Biome
Document Summary
Bio200 lecture 13 - drug metabolism, toxicity, and pro-drugs. Phase ii reactions = faster than p450-mediated phase i. Ex. / morphine-6-glucuronide is more potent than morphine alone. Low levels of drug metabolism, compared to liver ( except protein/peptide. Inhalation - helps to avoid the first-pass elimination process - goes straight to drugs ) bloodstream through lungs. Bronchi have diameter of 1-5mm - height and width of cells. Peptide and protein drugs metabolized higher up in the lungs. Tight junction between cells in these cells - only way to get transport and metabolism in airway epithelium through is one side of cell membrane. Contain p-glycoprotein efflux pump: drug efflux from cells (and thus. Metabolism and metabolite production also measured from lung tissue) monitored. We don"t want it to be metabolized here because we want a. And observed treatment of menopause symptoms, osteoporosis, and in some cancer treatment), similar to hepatic metabolism.
