BIO304H5 Lecture : #20 Taste and Smell

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emeralddog909

16 Dec 2011

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Type 1: k+ is activaley pumped into to clear k+ Type 2 (ignore whats on slide): detect sweet, umami, and bitter, activaete for calium to come through the cell. Type 3: 5-ht is serotonin, atp activates p2y which releseases 5-ht. Phospholipase c activates ip3 which allows intracellular ca+ to be released to activate panx1 and. Panx1 allows the release of atp and trpm5 allows na+ to come in (?: causes +ve charges to accumulate within the cell, for sour hydrogen opens.

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Dendritic cells can act as ______________ that signal the presence of infection. These cells can also be infected with virus. If the NK cells outnumber the infected dendritic cells, the NK cell will __________ the infected dendritic cells. This means that the __________ immunity triumphs over the viral infection.

If the infected dendritic cells outnumber the NK cells, they will mature into a form which goes to the ______ ______ ______ (3 words) where they will activate __ cells and initiate the __________ immunity.

Macrophages and NK cells act synergistically to mutually activate one another to fight off virus infections. Macrophages produce the chemokine _____________ to attract NK cells. They also produce the cytokines _________ and __________ to activate NK cells through the NK synapse. NK cell in turn produces _________, a type II interferon that activates macrophages to increase phagocytosis and produce more cytokines.

Indicate by writing âyesâ or ânoâ whether amplification of a signal could occur at the particular steps described below. Explain your answers.

A. An extracellular signaling molecule binds and activates a GPCR.

B. The activated GPCRs cause GÎ± to separate from GÎ² and GÎ³.

C. Adenylyl cyclase produces cyclic AMP.

D. cAMP activates protein kinase A.

E. Protein kinase A phosphorylates target proteins.

indigoferret604

Indicate by writing âyesâ or ânoâ whether amplification of a signal could occur at the particular steps described below. Explain your answers.

A. An extracellular signaling molecule binds and activates a GPCR.

B. The activated GPCRs cause GÎ± to separate from GÎ² and GÎ³.

C. Adenylyl cyclase produces cyclic AMP.

D. cAMP activates protein kinase A.

E. Protein kinase A phosphorylates target proteins.

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BIO304H5 Lecture : #20 Taste and Smell

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