BIO372H5 Lecture Notes - Lecture 5: Homologous Recombination, Homologous Chromosome, Genetic Recombination
Document Summary
Most multicellular organisms have 2 sets of chromosomes (diploid) One is from the mother and one from the father. Diploid cells have 2 homologous copies of each chromosome. Despite the high degree of similarity, they can carry different dna sequence variants of the same gene, known as alleles. Allele is one of two alternative forms of the same gene that have slightly different. Alleles are found at the same place on a chromosome. A and a, b and b, c and specify different alleles. A and a are the same gene but different sequences. Genetic exchange works constantly to bledna dn rearrange chromosome. Genetic exchange between homologous chromosome is the result of homologous recombination. A type of genetic recombination in which dna sequences are exchanged between 2 similiar dna molecule. 1- dna breaks are common and initiate recombination. If dsbs are not repaired, the consequence to cell is disastrous. To repair dsbs, most of cells is homologous recombination.
