BIOA01H3 Lecture Notes - Lecture 11: Thalidomide, Morning Sickness, Teratology

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BIOA01H3 Full Course Notes
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BIOA01H3 Full Course Notes
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Evolutionary developmental biology: genetic tool-kits control growth and development, changes in the development switches causes changes in gene expression. Hox genes: control/lay out the animal body plan: homeobox, a 180-nucleotide sequence, codes for homeodomain, a part of a transcription factor. Teratogens interfere with hox genes: retinoic acid is a teratogen which is very helpful since it controls the spread of acne. If it is taken during pregnancy, it can interfere with the hox gene and affect the fetus: thalidomide: was used to help control morning sickness, affects the offspring by not having any limbs. Distal-less gene (dil): it is important for the formation of appendages but can also be used to produce other characteristics, such as in the waterspider (hooks and spikes) and the butterfly (spots to ward off predators) Waterspider: the male hooks himself on top of the female to reproduce.

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