BIOA01H3 Lecture Notes - Lecture 30: Ferritin, Repressor, Response Element

• School: UTSC
• Department: Biological Sciences
• Course: BIOA01H3
• Professor: Karolyn Keir

Document Summary

[dna lv] (process) methyl gps added to histone tails -> further compaction of nucleosomes -> gene silencing. Settlation w/x methylation (mono or tri) -> loosening // reposition nucleosomes -> have access to dna -> can transcribe = gene reactivating. Embryonic stem cells (inner cell mass): pluripotent (can become any body cell) Patients w/ early life adversity: low lv of gr @ hippocampus -> overactive hpa axis -> development of anxiety traits -> suicide crisis (stress -> hypothalamus -> Crh & avp -> anterior pituitary -> acth -> adrenal cortex -> cortisol => shd be repressed but x @ patients); higher lv of methylation = higher lv of stress => (solution) reactivate the area silenced. Xist gene: noncoding rna that binds w/ x-chromo inactivation centre (xic); only expressed when 2 x chromo -> only 1 x -> inactive xic -> x transcription. => (when 2 x chromo) entire x chromo coated w/ xist rna -> xist rna triggers.