Instructions: Select 2 potential antidotes only from those listed in the box at the bottom.
More than 2 correct answers are possible. For credit you must submit this in class on TUES., Feb. 21 See the 2 sample answers for atropine & physostigmine.
POISON Mode of Action ANTIDOTE
Select 2 from those listed in the box below!
Atropine blocks neurotransmitter (2), (6)
(from belladonna) acetylcholine binding to
post-synaptic receptors
Nicotine mimics the action of acetylcholine
(from tobacco) in NMJ
Physostigmine inhibitor of acetylcholinesterase (4), (5)
(in calabar bean) (in NMJ)
Botulinum Toxin [Botox] blocks vesicles from releasing
(causes botulism) acetylcholine into NMJ
Digoxin inhibitor of Na+/K+ ATPase
(cardiac medication) pump in axon membrane
Black widow venom enhances release of acetylcholine into NMJ
(latrotoxin) by synaptic vesicles
Pufferfish toxin blocks closed Na+ gates of axon
(tetrodotoxin)
NMJ = neuromuscular junction (synapse between neuron & muscle cell)
POTENTIAL ANTIDOTES:
(1) atropine; (2) nicotine; (3) physostigmine; (4) botulinum toxin;
(5) digoxin; (6) black widow venom; (7) pufferfish toxin