BIOB10H3 Lecture Notes - Cytoplasm, Rna Interference, Semiconservative Replication

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13 Oct 2011
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mRNA stability and microRNAs
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mRNA stability
Lifetimes of eukaryotic mRNA vary
Poly(A) tail length may play a role
Poly(A) tail reduced as mRNA resides in cytoplasm
Certain destabilizing proteins in the 3’ UTR may
affect the rate of poly(A) tail shortening
When the tail is about 30 A residues
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mRNA stability
Once 3’ tail is removed message is decapped
and degraded from 5’ end
Deadenylation, decapping, and 5’ 3’
degradation occur within small transient
cytoplasmic granules
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